Consolidation of temporal order in episodic memories

AbstractEven though it is known that sleep benefits declarative memory consolidation, the role of sleep in the storage of temporal sequences has rarely been examined. Thus we explored the influence of sleep on temporal order in an episodic memory task followed by sleep or sleep deprivation. Thirty-four healthy subjects (17 men) aged between 19 and 28 years participated in the randomized, counterbalanced, between-subject design. Parameters of interests were NREM/REM cycles, spindle activity and spindle-related EEG power spectra. Participants of both groups (sleep group/sleep deprivation group) performed retrieval in the evening, morning and three days after the learning night. Results revealed that performance in temporal order memory significantly deteriorated over three days only in sleep deprived participants. Furthermore our data showed a positive relationship between the ratios of the (i) first NREM/REM cycle with more REM being associated with delayed temporal order recall. Most interestingly, data additionally indicated that (ii) memory enhancers in the sleep group show more fast spindle related alpha power at frontal electrode sites possibly indicating access to a yet to be consolidated memory trace. We suggest that distinct sleep mechanisms subserve different aspects of episodic memory and are jointly involved in sleep-dependent memory consolidation

Predicting Java Computer Programming Task Difficulty Levels Using EEG for Educational Environments

Understanding how difficult a learning task is for a person allows teaching material to be appropriately designed to suit the person, especially for programming material. A first step for this would be to predict on the task difficulty level. While this is possible through subjective questionnaire, it could lead to misleading outcome and it would be better to do this by tapping the actual thought process in the brain while the subject is performing the task, which can be done using electroencephalogram. We set out on this objective and show that it is possible to predict easy and difficult levels of mental tasks when subjects are attempting to solve Java programming problems. Using a proposed confidence threshold, we obtained a classification performance of 87.05% thereby showing that it is possible to use brain data to determine the teaching material difficulty level which will be useful in educational environments

Specific heat and thermal conductivity in the vortex state of the two-gap superconductor MgB_2

The specific heat coefficient gamma_s(H) and the electronic thermal conductivity kappa_{es}(H) are calculated for Abrikosov's vortex lattice by taking into account the effects of supercurrent flow and Andreev scattering. First we solve the gap equation for the entire range of magnetic fields. We take into account vertex corrections due to impurity scattering calculated in the Born approximation. The function gamma_s(H)/gamma_n increases from zero and becomes approximately linear above H/H_{c2} \sim 0.1. The dependence on impurity scattering is substantially reduced by the vertex corrections. The upward curvature of kappa_{es}(H)/kappa_{en}, which is caused by decreasing Andreev scattering for increasing field, is reduced for increasing impurity scattering. We also calculate the temperature dependence of the scattering rates 1/tau_{ps}(H) of a phonon and 1/tau_{es}(H) of a quasiparticle due to quasiparticle and phonon scattering, respectively. At low temperatures the ratio tau_{pn}/tau_{ps}(H) increases rapidly to one as H tends to H_{c2} which yields a rapid drop in the phononic thermal conductivity kappa_{ph}. Our results are in qualitative agreement with the experiments on the two-gap superconductor MgB_2.Comment: 12 pages, 5 figures, additions to figures 1, 2, and 3. Accepted by Phys. Rev.

Changes in brain electrical activity during extended continuous word recognition

Twenty healthy subjects (10 men, 10 women) participated in an EEG study with an extended continuous recognition memory task, in which each of 30 words was randomly shown 10 times and subjects were required to make old vs. new decisions. Both event-related brain potentials (ERPs) and induced band power (IBP) were investigated. We hypothesized that repeated presentations affect recollection rather than familiarity. For the 300- to 500-ms time window, an 'old/new' ERP effect was found for the first vs. second word presentations. The correct recognition of an 'old' word was associated with a more positive waveform than the correct identification of a new word. The old/new effect was most pronounced at and around the midline parietal electrode position. For the 500- to 800-ms time window, a linear repetition effect was found for multiple word repetitions. Correct recognition after an increasing number of repetitions was associated with increasing positivity. The multiple repetitions effect was most pronounced at the midline central (Cz) and fronto-central (FCz) electrode positions and reflects a graded recollection process: the stronger the memory trace grows, the more positive the ERP in the 500- to 800-ms time window. The ERP results support a dual-processing model, with familiarity being discernable from a more graded recollection state that depends on memory strengths. For IBP, we found 'old/new' effects for the lower-2 alpha, theta, and delta bands, with higher bandpower during 'old' words. The lower-2 alpha 'old/new' effect most probably reflects attentional processes, whereas the theta and delta effects reflect encoding and retrieval processes. Upon repeated word presentations, the magnitude of induced delta power in the 375- to 750-ms time window diminished linearly. Correlation analysis suggests that decreased delta power is moderately associated with faster decision speed and higher accurac

Dejian mind-body intervention improves the functioning of a patient with chronic epilepsy: a case report

Author name used in this publication: Mei-chun Cheung2009-2010 > Academic research: refereed > Publication in refereed journalpublished_fina

The influence of methylphenidate on the power spectrum of ADHD children – an MEG study

BACKGROUND: The present study was dedicated to investigate the influence of Methylphenidate (MPH) on cortical processing of children who were diagnosed with different subtypes of Attention Deficit Hyperactivity Disorder (ADHD). As all of the previous studies investigating power differences in different frequency bands have been using EEG, mostly with a relatively small number of electrodes our aim was to obtain new aspects using high density magnetoencephalography (MEG). METHODS: 35 children (6 female, 29 male) participated in this study. Mean age was 11.7 years (± 1.92 years). 17 children were diagnosed of having an Attention-Deficit/Hyperactivity Disorder of the combined type (ADHDcom, DSM IV code 314.01); the other 18 were diagnosed for ADHD of the predominantly inattentive type (ADHDin, DSM IV code 314.0). We measured the MEG during a 5 minute resting period with a 148-channel magnetometer system (MAGNES™ 2500 WH, 4D Neuroimaging, San Diego, USA). Power values were averaged for 5 bands: Delta (D, 1.5–3.5 Hz), Theta (T, 3.5–7.5 Hz), Alpha (A, 7.5–12.5 Hz), Beta (B, 12.5–25 Hz) and Global (GL, 1.5–25 Hz).). Additionally, attention was measured behaviourally using the D2 test of attention with and without medication. RESULTS: The global power of the frequency band from 1.5 to 25 Hz increased with MPH. Relative Theta was found to be higher in the left hemisphere after administration of MPH than before. A positive correlation was found between D2 test improvement and MPH-induced power changes in the Theta band over the left frontal region. A linear regression was computed and confirmed that the larger the improvement in D2 test performance, the larger the increase in Theta after MPH application. CONCLUSION: Main effects induced by medication were found in frontal regions. Theta band activity increased over the left hemisphere after MPH application. This finding contradicts EEG results of several groups who found lower levels of Theta power after MPH application. As relative Theta correlates with D2 test improvement we conclude that MEG provide complementary and therefore important new insights to ADHD

Influence of Fermi surface topology on the quasiparticle spectrum in the vortex state

We study the influence of Fermi surface topology on the quasiparticle density of states in the vortex state of type II superconductors. We observe that the field dependence and the shape of the momentum and spatially averaged density of states is affected significantly by the topology of the Fermi surface. We show that this behavior can be understood in terms of characteristic Fermi surface functions and that an important role is played by the number of points on the Fermi surface at which the Fermi velocity is directed parallel to the magnetic field. A critical comparison is made with a broadened BCS type density of states, that has been used frequently in analysis of tunneling data. We suggest a new formula as a replacement for the broadened BCS model for the special case of a cylindrical Fermi surface. We apply our results to the two gap superconductor MgB$_2$ and show that in this particular case the field dependence of the partial densities of states of the two gaps behaves very differently due to the different topologies of the corresponding Fermi surfaces, in qualitative agreement with recent tunneling experiments.Comment: 12 pages 12 figure

Ultrasonic attenuation in magnetic fields for superconducting states with line nodes in Sr2RuO4

We calculate the ultrasonic attenuation in magnetic fields for superconducting states with line nodes vertical or horizontal relative to the RuO_2 planes. This theory, which is valid for fields near Hc2 and not too low temperatures, takes into account the effects of supercurrent flow and Andreev scattering by the Abrikosov vortex lattice. For rotating in-plane field H(theta) the attenuation alpha(theta)exhibits variations of fourfold symmetry in the rotation angle theta. In the case of vertical nodes, the transverse T100 sound mode yields the weakest(linear)H and T dependence of alpha, while the longitudinal L100 mode yields a stronger (quadratic) H and T dependence. This is in strong contrast to the case of horizontal line nodes where alpha is the same for the T100 and L100 modes (apart from a shift of pi/4 in field direction) and is roughly a quadratic function of H and T. Thus we conclude that measurements of alpha in in-plane magnetic fields for different in-plane sound modes may be an important tool for probing the nodal structure of the gap in Sr_2RuO_4.Comment: 5 pages, 6 figures, replaced in non-preprint form, to appear in Phys. Rev.